Dabo Swinney and Brian Kelly lead their teams in a Top-5 matchup. Can Clemson pull out a win without Trevor Lawrence? GETTY IMAGES

The Clemson Tigers will still be without their leader quarterback Trevor Lawrence as they take on the Notre Dame Fighting Irish. That will be a major concern in the only Top-5 matchup of the weekend. While Lawrence still can't play after testing positive for COVID-19 before last week's game, he is reportedly out of his 10-day isolation period and he will be able to join his teammates on the sidelines. He will likely play after a bye week if everything continues to improve with his health against Florida State.

Their matchup against Notre Dame was going to be their biggest obstacle of the regular season whether Lawrence was playing or not. The Irish are undefeated and a force of their own playing for the first time in football in the ACC. Clemson is still the favorite because of their elite offense and defense that can hang with Notre Dame's. The Irish haven't been as dominant as Clemson has in their undefeated runs.

But Clemson is on serious upset alert. They only beat Boston College 34-28 last week behind backup QB D.J. Uiagalelei, who took over for Lawrence. Uiagalelei passed for 342 yards against the Eagles and accounted for three scores but had to make a tremendous comeback to fend off the upset victory. Clemson was down 18 points at half to a team they otherwise would have beat in their sleep. To be fair, Boston College's only loses were against ranked North Carolina and Virginia Tech before they lost to Clemson, but it should have never been that close.

What TV Channel is Clemson-Notre Dame on?

Clemson-Notre Dame will be shown on NBC at 7:30 p.m. ET. You can live stream College Games on fuboTV.

How to Watch Clemson-Notre Dame

When: Saturday, November 7
Where: Notre Dame Stadium, Notre Dame, IN
Time: 7:30 p.m. ET
Live Stream: fuboTV (watch football free with fuboTV)

The Irish have plenty of incentive to beat Clemson no matter who's starting at QB. In the 2018-19 College Football Playoff, #2 Clemson and Lawrence pummeled #3 Notre Dame in the Cotton Bowl 30-3 on their way to winning the National Championship in Lawrence's first year at the helm. Notre Dame QB Ian Book was starting that game. Ever since then, they have been trying to get back to a Top-4 position and this is their best chance yet to knock off the Tigers.

Notre Dame is much more prepared to take off Clemson from their number one ranking than Boston College was. No matter the outcome though, this is likely to be the matchup for the ACC Championship. Notre Dame could have the opportunity to prove themselves twice and get revenge on their 2018 loss. Even though they won't play Lawrence today, whoever wants to win the national championship just like last year will have to get through the best quarterback in the country and the Clemson Tigers.

Clemson-Notre Dame Betting Odds

Clemson Odds: -5.5

Notre Dame Odds: +5.5

Money Line: Clemson -210 , Notre Dame +180

Over/Under: 50