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2022 NCAA Tournament Odds, Picks, Line, Spread: Indiana vs. Wyoming Predictions and Best Bets

Indiana faces Wyoming on Tuesday in the First Four. Below are predictions and best bets for Tuesday’s game.

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Indiana vs. Wyoming Game Time and Odds

  • Game Day: Tuesday, March 15, 2022
  • Game Time: 9:10 PM ET
  • Location: Dayton, Ohio
  • Stadium: University of Daytona Arena
  • Moneyline favorite: Indiana (-190)
  • Spread: Hoosiers (-4)
  • Total: 132.5

Indiana went 20-13 this season, while Wyoming went 25-8. The winner of this game moves on to face St. Mary’s in the first round in a 5/12 matchup.

So, let’s look at some bets that you could make on this game.

HOOSIERS VS. COWBOYS PREDICTIONS

BEST BET: TAKE INDIANA ON THE MONEYLINE (-190)

Indiana is 36th in KenPom. Wyoming is 58th. Nice little gap there. Indiana has wins over ranked teams Ohio State, Purdue and Illinois. Both teams have four wins against Quad 1 teams, though Indiana does have more Quad 1 losses. But on the other end, Indiana wins the games it should win, going 12-1 against Quad 3 and Quad 4 teams, while Wyoming lost twice to Quad 3 teams.

Overall, I trust this Indiana team to win this game more than I trust this Wyoming team. Indiana is battle-tested. Wyoming isn’t — or, at least, isn’t as much.

BEST BET: TAKE THE SPREAD FOR INDIANA (-4)

I wish this would drop a half point because I’d feel much better if this was a -3.5, but I still think the best bet when it comes to the spread is to take Indiana. The Hoosiers have won their last four games against the spread. The team is 21st in KenPom’s adjusted defensive, while Wyoming is 54th in adjusted offense. I lean toward the Hoosier defense in that case, which should create some separation between the two teams.

BEST BET: TAKE THE UNDER (132.5)

Both teams have solid defenses. Both teams rank outside of the top 150 in pace. Possessions will be at a premium here, which has me leaning toward taking the under on total points.

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