Chicago White Sox vs Arizona Diamondbacks Live Stream: How to Watch MLB

The White Sox go for the series win against the Diamondbacks on Wednesday night.

After taking the first game of the series, the White Sox go for the series win against the Diamondbacks at Chase Field in Phoenix on Wednesday night. 

Despite winning two straight games on the road in Arizona, the White Sox remain five games below .500 with a 9-14 record and a 6-8 mark on the road. Chicago is 4-6 over its last 10 games with a -25 run differential on the season. Arizona, on the other hand, has lost two straight but is still 13-10 on the season with a 7-4 record at home and a 6-4 mark in its last 10 games. The Diamondbacks will send lefty Eduardo Rodriguez to the mound against White Sox lefty Anthony Kay. 

How to Watch White Sox vs Diamondbacks Today

Game Date: April 22, 2026

Game Time: 9:30 p.m. ET

TV: Chicago Sports Network, MLB.TV – Arizona Diamondbacks

Location: Chase Field

Live Stream White Sox vs Diamondbacks On Fubo: Start watching now!

Most recently, the White Sox offense erupted for seven runs in the first two innings to take an 11-5 victory over the Diamondbacks in Arizona on Tuesday night. Rookie Munetaka Murakami homered for the fourth straight game and Sean Burke snapped his winless starts streak with six strong innings. 

The Diamondbacks and White Sox continue their series in Arizona on Wednesday night. 

What Time Is White Sox vs Diamondbacks?

The White Sox vs Diamondbacks will take place on Wednesday April 22, 2026 at 9:30 p.m. ET. Tune in and catch some great MLB action.

What Channel Is the White Sox vs Diamondbacks Game On?

Looking to watch this game? Fans can tune into Chicago Sports Network, MLB.TV – Arizona Diamondbacks to see the action. Make sure you subscribe to Fubo now to watch this matchup, as well as numerous other sports leagues.

Watch the White Sox vs Diamondbacks Game on Fubo: Start watching now!

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