MLB

Cleveland Guardians at Minnesota Twins – Where to Watch, Stream Info, TV Channel, and Live Updates (September 21, 2025)

September 21, 2025 by Fubo Sports Desk
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The Cleveland Guardians, boasting an impressive record of 84-71, are set to face the Minnesota Twins, who currently sit at 66-89. The Guardians enter this matchup on a remarkable 10-game winning streak, showcasing their strong performance as they vie for playoff positioning. In contrast, the Twins are struggling, having lost their last five games. Cleveland’s success has been bolstered by standout players such as José Ramírez, who leads the team with 30 home runs and 100 runs scored. Meanwhile, Minnesota’s Byron Buxton has been a key contributor, leading the team in multiple offensive categories, including home runs and RBIs. This game presents a critical opportunity for the Guardians to solidify their momentum against a reeling Twins squad.

Cleveland Guardians at Minnesota Twins Game Information

Game Date: September 21, 2025
Game Time: 02:10 PM ET
TV Channel: Cleveland Guardians, Minnesota Twins, MLB.TV – Cleveland Guardians
Location: Target Field, Minneapolis, MN
Live Stream: Fubo (free trial)

Live Updates

4:46 PM ET
Daniel Schneemann flies out to left field to Austin Martin.
4:45 PM ET
Daniel Schneemann pinch-hitting for Angel Martínez.
4:44 PM ET
Petey Halpin strikes out swinging.
4:43 PM ET
Petey Halpin pinch-hitting for Gabriel Arias.
4:43 PM ET
Bo Naylor grounds out to shortstop, Brooks Lee to Kody Clemens.
4:39 PM ET
Travis Adams (P) replaces Cole Sands (P).
4:37 PM ET
Ryan Fitzgerald grounds out to first base to Kyle Manzardo.
4:34 PM ET
Jhonny Pereda doubles to right field.
4:33 PM ET
Brooks Lee strikes out swinging.
4:31 PM ET
James Outman strikes out swinging.
4:28 PM ET
Zak Kent (P) replaces Hunter Gaddis (P).
4:27 PM ET
Kyle Manzardo strikes out swinging.
4:25 PM ET
José Ramírez singles to deep right field.
4:23 PM ET
George Valera flies out to center field to Byron Buxton.
4:21 PM ET
Steven Kwan lines out to left field to Austin Martin.
4:19 PM ET
Cole Sands (P) replaces Pierson Ohl (P).
4:19 PM ET
Ryan Fitzgerald switches from 3B to 2B.
4:19 PM ET
James Outman (RF) replaces Edouard Julien (1B), batting 6th.
4:19 PM ET
Royce Lewis remains in the game as 3B.
4:19 PM ET
Kody Clemens switches from 2B to 1B.
4:18 PM ET
Luke Keaschall strikes out swinging.
4:16 PM ET
Royce Lewis homers to left field. Austin Martin scores. Kody Clemens scores.
4:14 PM ET
Royce Lewis pinch-hitting for Trevor Larnach.
4:13 PM ET
Hunter Gaddis (P) replaces Tim Herrin (P).
4:11 PM ET
Austin Martin singles to third base. Kody Clemens to third. Throwing error by José Ramírez.
4:10 PM ET
Kody Clemens singles to third base.
4:08 PM ET
Byron Buxton strikes out swinging.
4:07 PM ET
Ryan Fitzgerald grounds out to shallow infield, Tim Herrin to Kyle Manzardo.
4:05 PM ET
Tim Herrin (P) replaces Matt Festa (P).
4:03 PM ET
Brayan Rocchio flies out to shallow center field to Austin Martin.
4:01 PM ET
CJ Kayfus flies out to shallow center field to Byron Buxton.
4:01 PM ET
Angel Martínez pops out to Jhonny Pereda.
3:58 PM ET
Pierson Ohl (P) replaces Kody Funderburk (P).
3:57 PM ET
Jhonny Pereda pops out to shallow right field to Brayan Rocchio.
3:56 PM ET
Brooks Lee homers to right field. Luke Keaschall scores.
3:54 PM ET
Matt Festa (P) replaces Erik Sabrowski (P).
3:53 PM ET
Edouard Julien grounds out to second base, Brayan Rocchio to Kyle Manzardo. Luke Keaschall to third.
3:51 PM ET
Luke Keaschall doubles to right field.
3:48 PM ET
Trevor Larnach strikes out swinging.
3:45 PM ET
Gabriel Arias flies out to right field to Trevor Larnach.
3:43 PM ET
Bo Naylor flies out to deep right center field to Trevor Larnach.
3:42 PM ET
Kyle Manzardo strikes out swinging.
3:39 PM ET
Kody Funderburk (P) replaces Simeon Woods Richardson (P).
3:38 PM ET
Austin Martin pops out to Kyle Manzardo.
3:37 PM ET
Kody Clemens pops out to shortstop to Gabriel Arias.
3:35 PM ET
Erik Sabrowski (P) replaces Joey Cantillo (P).
3:34 PM ET
Byron Buxton walks. Jhonny Pereda to second. Brooks Lee to third.
3:31 PM ET
Ryan Fitzgerald pops out to shortstop to Gabriel Arias.
3:29 PM ET
Jhonny Pereda singles to shallow infield. Brooks Lee to second.
3:27 PM ET
Brooks Lee singles to deep left field.
3:25 PM ET
José Ramírez grounds out to first base, Edouard Julien to Simeon Woods Richardson.
3:23 PM ET
George Valera walks. Brayan Rocchio to second.
3:20 PM ET
Steven Kwan pops out to first base to Kody Clemens.
3:18 PM ET
Brayan Rocchio reaches on error. Throwing error by Ryan Fitzgerald.
3:16 PM ET
CJ Kayfus grounds out to shallow right field, Edouard Julien to Simeon Woods Richardson.
3:14 PM ET
Edouard Julien lines out to first base to Kyle Manzardo.
3:13 PM ET
Luke Keaschall strikes out swinging.
3:11 PM ET
Trevor Larnach strikes out swinging.
3:08 PM ET
Angel Martínez grounds out to first base to Edouard Julien.
3:07 PM ET
Gabriel Arias strikes out on a foul tip.
3:05 PM ET
Bo Naylor lines out to right field to Trevor Larnach.
3:02 PM ET
Austin Martin called out on strikes.
2:59 PM ET
Kody Clemens singles to left field. Byron Buxton scores.
2:57 PM ET
Byron Buxton doubles to right field.
2:55 PM ET
Ryan Fitzgerald pops out to shallow center field to Gabriel Arias.
2:54 PM ET
Jhonny Pereda lines out to right field to CJ Kayfus.
2:51 PM ET
Kyle Manzardo grounds out to second base, Kody Clemens to Edouard Julien.
2:50 PM ET
José Ramírez flies out to deep right field to Trevor Larnach.
2:49 PM ET
George Valera flies out to left field to Austin Martin.
2:45 PM ET
Brooks Lee strikes out swinging.
2:44 PM ET
Edouard Julien walks.
2:42 PM ET
Luke Keaschall grounds out to shortstop, José Ramírez to Kyle Manzardo.
2:41 PM ET
Trevor Larnach flies out to center field to Angel Martínez.
2:38 PM ET
Steven Kwan grounds out to second base, Kody Clemens to Edouard Julien.
2:36 PM ET
Brayan Rocchio singles to left center field.
2:35 PM ET
CJ Kayfus flies out to left field to Austin Martin.
2:34 PM ET
Angel Martínez flies out to deep center field to Byron Buxton.
2:31 PM ET
Austin Martin grounds out to shortstop, Gabriel Arias to Kyle Manzardo.
2:30 PM ET
Kody Clemens grounds out to shallow infield, Joey Cantillo to Kyle Manzardo.
2:29 PM ET
Byron Buxton strikes out swinging.
2:26 PM ET
Gabriel Arias strikes out on a foul tip.
2:23 PM ET
Bo Naylor out on a sacrifice fly to right center field to Byron Buxton. George Valera scores.
2:20 PM ET
Kyle Manzardo singles to center field. George Valera to third.
2:19 PM ET
José Ramírez strikes out swinging.
2:15 PM ET
George Valera walks.
2:13 PM ET
Steven Kwan homers to right field.

Minnesota Twins Team Statistics and Rankings

Win-Loss Record: 66-89
Home Record: 37-43
Away Record: 29-46
Division Record: 19-32
Streak: 5 Loss streak
Winning Percentage: .426

Cleveland Guardians Team Statistics and Rankings

Win-Loss Record: 84-71
Home Record: 41-34
Away Record: 43-37
Division Record: 34-14
Streak: 10 Win streak
Winning Percentage: .542

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Stat Leaders

Minnesota Twins (66-89, #4 in division)

Batting Average Leader: Jhonny Pereda, 0.320
RBI Leader: Byron Buxton, 76 RBI
Home Run Leader: Byron Buxton, 31 HR
Runs Leader: Byron Buxton, 91 Runs
Hits Leader: Byron Buxton, 123 Hits
Stolen Bases Leader: Byron Buxton, 24 SB
ERA Leader: Danny Coulombe, 1.16 ERA
Strikeout Leader: Joe Ryan, 185 K
Wins Leader: Joe Ryan, 13 W
Saves Leader: Jhoan Duran, 16 SV

Cleveland Guardians (84-71, #2 in division)

Batting Average Leader: Petey Halpin, 0.333
RBI Leader: José Ramírez, 81 RBI
Home Run Leader: José Ramírez, 30 HR
Runs Leader: José Ramírez, 100 Runs
Hits Leader: Steven Kwan, 165 Hits
Stolen Bases Leader: José Ramírez, 40 SB
ERA Leader: Erik Sabrowski, 1.78 ERA
Strikeout Leader: Gavin Williams, 161 K
Wins Leader: Tanner Bibee, 11 W
Saves Leader: Emmanuel Clase, 24 SV

Minnesota Twins Injury Report

David Festa – Shoulder (D15) – The Minnesota Twins placed RHP David Festa on the 15-day injured list with right shoulder inflammation.
Ryan Jeffers – Head (D7) – The Minnesota Twins placed C Ryan Jeffers on the 7-day injury list due to head contusion.
Matt Wallner – Oblique (D10) – The Minnesota Twins placed OF Matt Wallner on the 10-day injured list with a right oblique strain.
Justin Topa – Oblique (D15) – The Minnesota Twins placed RHP Justin Topa on the 15-day injured list with a left oblique strain.
Anthony Misiewicz – Shoulder (D15) – The Minnesota Twins placed RHP Anthony Misiewicz on the 15-day injured list with a left shoulder impingement.
Alan Roden – Thumb (D60) – The Minnesota Twins transferred OF Alan Roden to the 60-day injured list due to a thumb injury.
Pablo López – Forearm (D15) – The Minnesota Twins placed RHP Pablo López on the 15-day injured list due to a mild mid right forearm strain.
Christian Vázquez – Shoulder (D10) – The Minnesota Twins placed C Christian Vázquez on the 10-day injured list due to a left shoulder infection.

Cleveland Guardians Injury Report

Andrew Walters – Lat (D60) – The Cleveland Guardians transferred RHP Andrew Walters to the 60-day injured list with a right lat strain.
Sam Hentges – Shoulder (D60) – The Cleveland Guardians placed LHP Sam Hentges on the 60-day injured list as he recovers from shoulder capsule repair.
John Means – Elbow (D60) – The Cleveland Guardians transferred LHP John Means from the 15-day injured list to the 60-day injured list as he recovers from UCL revision.
Nic Enright – Elbow (D15) – The Cleveland Guardians placed RHP Nic Enright on the 15-day injured list with right elbow/forearm inflammation.
Ben Lively – Forearm (D60) – The Cleveland Guardians transferred C Max Stassi from the 15-day injured list to the 60-day injured list. Lively is set to undergo season-ending UCL surgery and will miss the remainder of the season.
Nolan Jones – Oblique (D10) – The Cleveland Guardians placed OF Nolan Jones on the 10-day injured list due to right oblique strain.
Will Brennan – Forearm (D60) – The Cleveland Guardians placed OF Will Brennan on the 60-day injured list with left forearm inflammation.
Lane Thomas – Foot (D10) – The Cleveland Guardians placed OF Lane Thomas on the 10-day injured list with a right plantar fasciitis.

Minnesota Twins Upcoming 2025 Schedule

September 21, 2025 vs Cleveland Guardians
September 23, 2025 at Texas Rangers
September 24, 2025 at Texas Rangers
September 25, 2025 at Texas Rangers
September 26, 2025 at Philadelphia Phillies
September 27, 2025 at Philadelphia Phillies
September 28, 2025 at Philadelphia Phillies

Cleveland Guardians Upcoming 2025 Schedule

September 21, 2025 at Minnesota Twins
September 23, 2025 vs Detroit Tigers
September 24, 2025 vs Detroit Tigers
September 25, 2025 vs Detroit Tigers
September 26, 2025 vs Texas Rangers
September 27, 2025 vs Texas Rangers
September 28, 2025 vs Texas Rangers

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