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Cleveland Guardians vs St. Louis Cardinals Live Stream: How to Watch MLB

April 15, 2026 by Ben Macaluso
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The St. Louis Cardinals look to win this only series against the Cleveland Guardians on Wednesday at home in this finale.

The St. Louis Cardinals host the Cleveland Guardians in the rubber match in the season series finale on Wednesday. This is the first and only series of the season between these interleague foes. St. Louis tied the series on Tuesday with a walk-off 6-5 win in 10 innings. The win ended a three-game losing streak for St. Louis and got the Cardinals a game back over .500. It was a nice bounce back for St. Louis after Cleveland dominated in the opener, 9-3. St. Louis may not have had the highest projections it has ever had coming into the season, but the Cardinals’ outfielder Jordan Walker is smashing those perceptions. Walker hit his MLB-leading eighth homer already on Monday in the opener of Cleveland. He also has a .328 average with 15 RBIs, leading the team in both categories. It looks like he could be the next big name amongst the hallowed sluggers in St. Louis, where baseball reigns supreme. This finale will be considered a tossup with the Cardinals being the slight -115 favorite.

How to Watch Cleveland Guardians vs St. Louis Cardinals Today:

Game Date: Wednesday, April 15, 2026

Game Time: 1:15 p.m. ET

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TV: MLB Network

Location: Busch Stadium – St. Louis, MO

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St. Louis tied this series on the shoulders of Cardinals rookie JJ Wetherholt, who homered twice. St. Louis completed the comeback in extras after trailing in the eighth inning, 5-2. DH Yohel Pozo drove in the tying run in the bottom of the ninth, and Nathan Church walked off the game by hitting a sac fly in the bottom of the 10th. It was particularly a bitter pill to swallow for Cleveland, as Masyn Winn hit a game-ending grounder to the Guardians Juan Brito, but it turned into an error bouncing into right field. It thwarted a three-run eighth inning that nearly put the game out of reach on two RBI doubles from George Valera and Angel Martinez.

Dustin May will try to get on track after his first few starts with his new team, getting the start today for the Cardinals. The righty is 1-2 with a 9.45 ERA in 13.1 innings across three starts. Slae Cecconi is looking for his first win of the season for Cleveland. The right-hander is 0-2 with a 5.74 ERA in 15.2 innings across three starts.

What time is the Cleveland Guardians vs St. Louis Cardinals?

The Cleveland Guardians vs St. Louis Cardinals game will take place on Wednesday, April 15, 2026 at 1:15 p.m. ET. Tune in and catch some great MLB action.

What Channel Is the Cleveland Guardians vs St. Louis Cardinals On?

Looking to watch this game? Fans can tune in to MLB Network to see the action. Make sure you subscribe to Fubo now to watch this matchup, as well as numerous other sports leagues.

Live stream the Cleveland Guardians vs St. Louis Cardinals game on Fubo: Start watching now!

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