Houston Astros

Houston Astros vs Cleveland Guardians Live Stream: How to Watch MLB

April 22, 2026 by Brandon Rush
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Astros wrap their road trip in a matinee finale against the Guardians 

Winners of four of their last six games, the division-leading Cleveland Guardians conclude their seven-game home stand on Wednesday afternoon as they play host to the Houston Astros in the rubber game of their three-game mid-week series. The Astros have lost five of their last six games and nine of the last 10 on the road having allowed seven or more runs four times in their last five outings. The Guardians will send their ace Tanner Bibee (0-2, 4.81 ERA) to the mound in search of his first win of the season while the Astros will open with reliever Peter Lambert (0-1, 7.20 ERA) in his second outing of the season.

How to Watch Houston Astros vs Cleveland Guardians:

Date: April 22, 2026  

Time: 1:00 p.m. ET

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TV Channel: Space City Home Network, Cleveland Guardians (NEW), MLB Network

Location: Progressive Field

Live Stream the Houston Astros vs Cleveland Guardians game on Fubo: Start watching now!

Astros left fielder Yordan Alvarez leads the team in virtually every offensive category and leads Major League Baseball with 10 home runs and 24 RBIs in his first 25 games this season. Alvarez, a three-time All-Star, won the 2019 AL Rookie Of the Year Award and was named MVP of the ALCS in 2021, later helping the Astros win the World Series in 2022, finishing third in MVP voting trailing only Shoei Ohtani and Aaron Judge.

Hitting a team-leading .284 this season, Guardians shortstop Brayan Rocchio comes into Wednesday on an eight-game hit streak with three multi-hit efforts in that span. Rocchio, now in his fourth season in Cleveland, is having a breakout season and is on pace to shatter his career highs in hits, homers, and RBIs which he set last season.

What time is Astros vs Guardians?

Coverage of the Houston Astros vs Cleveland Guardians starts Wednesday, April 22, at 1:00 p.m ET. Tune in to see if the Astros can win in Cleveland for the seventh time in the last 11 games or if the Guardians can take the series victory.

What channel is the Astros vs Guardians game on?

Looking to watch the game? Subscribers can tune to Space City Home Network, Cleveland Guardians (NEW) or MLB Network to catch the action. Make sure you subscribe to Fubo now to watch this matchup at home or on the go with the Fubo TV app.

Watch the Houston Astros vs Cleveland Guardians game on Fubo: Start watching now!

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