How to Watch Astros at Cardinals (April 16): Stream MLB Live, TV Channel

The Houston Astros and the St. Louis Cardinals decide their three-game interleague series at Busch Stadium on Wednesday.

The Houston Astros (8-9) and St. Louis Cardinals (8-9) meet on Wednesday afternoon at Busch Stadium in St. Louis in the rubber game of their three-game interleague series as both teams look to get back to the .500 mark early in the MLB season. Houston has alternated wins and losses over its last 11 games and can get consecutive victories for the first time in 2025 with a win on Wednesday. It’s a getaway day for both teams. the Astros start a six-game homestand on Friday, while St. Louis opens a seven-game road trip on Thursday.

How to Watch Houston Astros at St. Louis Cardinals in MLB Today:

Game Date: Wednesday, April 16, 2025

Game Time: 1 p.m. ET

TV: FanDuel Sports Network Indiana

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Jake Meyers broke a scoreless tie with an RBI single in the sixth inning and Yordan Alvarez provided an insurance run with a laser blast to center field in the eighth inning, as Houston took a 2-0 decision on Tuesday night. Hunter Brown worked six scoreless innings and Josh Hader needed just 10 pitches in a 1-2-3 ninth for his fourth save. Jose Altuve is hitting .300/.333/.443 with three homers and seven RBIs so far, with Isaac Paredes and Jeremy Peña sharing the club lead with three home runs. Alvarez has 10 RBIs and Meyers snapped an 0-for-9 funk with his go-ahead hit.

The Cardinals had six hits in the loss and Brendan Donovan extended his hitting streak to an MLB-best 11 games with a fourth-inning double. Erick Fedde took the hard-luck loss after allowing a run on six hits over six innings while fanning five. Donovan is slashing .382/.411/.559 with a pair of homers and 11 RBIs, as the sputtering offense is managing just 2.1 runs per game so far.

Left-hander Steven Matz is set to make his first start of the season on Wednesday after five relief outings for St. Louis. He has a 2.31 ERA and 1.11 WHIP in 11.2 innings. Right-hander Ronel Blanco (1-1) is scheduled to go for the Astros, coming in with a 6.94 ERA and 1.71 WHIP in three starts and 11.2 innings. He comes off his best outing of the season on Friday with seven strikeouts and two runs allowed in five innings of a win over the Los Angeles Angels.

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