How to Watch White Sox at Cubs (May 16): Stream MLB Live, TV Channel

The Chicago Cubs look to bounce back from a loss when they host the Chicago White Sox on Friday afternoon.

City bragging rights are on the line this weekend as the Chicago Cubs host the rival Chicago White Sox beginning on Friday. The two teams are at opposite ends of their respective divisions, as the Cubs sit in first place in the National League Central, while the White Sox are in last place in their division. The Cubs come into Friday 25-19 and are clinging to the lead in the NL Central, as the St. Louis Cardinals have been hot on their heels. The Cubs took the first two games of their current homestand against the Miami Marlins, but couldn’t complete the sweep and lost 3-1 in the finale on Wednesday. Friday they will look to get back in the win column when they send Cade Horton to the mound. It will be his first-ever start and second appearance in his career. Horton pitched four innings on Saturday against the New York Mets. He gave up four hits and three runs, but earned the win as the Cubs won 6-5.

How to Watch Chicago White Sox at Chicago Cubs Today:

Game Date: Friday, May 16, 2025

Game Time: 2:00 p.m. ET

TV: Marquee Sports Network

Live stream the White Sox at Cubs game on Fubo: Start your free trial now!

The White Sox are hoping they can ruin his first-ever start as they try to pick up a much-needed win over the Cubs.

The White Sox will turn to Shane Smith in the series opener. Smith comes into Friday 1-2 with a 2.08 ERA.

The White Sox have struggled with him on the mound, as they have lost seven of his eight starts, including the last two.

He did pitch great in his last start, as he went six innings without giving up a run to the Miami Marlins on Saturday. The White Sox still lost the game 3-1.

Regional restrictions may apply.