MLB

St. Louis Cardinals at San Francisco Giants – Where to Watch, Stream Info, TV Channel, and Live Updates (September 22, 2025)

September 22, 2025 by Fubo Sports Desk
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The St. Louis Cardinals (76-80) are set to face the San Francisco Giants (77-79) in a matchup featuring two teams currently on one-game win streaks. Both teams find themselves in the fourth position in their respective divisions, with the Giants holding a slight edge in overall record. The Giants have a home record of 38-37, while the Cardinals have struggled on the road with a 32-43 record. Key players for the Giants include Willy Adames, who leads the team in multiple offensive categories, and Erik Miller, who boasts a 1.50 ERA. For the Cardinals, José Fermín leads with a .300 batting average, while Willson Contreras has contributed 80 RBIs despite being on the injured list. This game promises to be a competitive encounter as both teams look to improve their standings.

St. Louis Cardinals at San Francisco Giants Game Information

Game Date: September 22, 2025
Game Time: 09:45 PM ET
TV Channel: FanDuel Sports Network Indiana, NBC Sports Bay Area, MLB.TV – San Francisco Giants
Location: Oracle Park, San Francisco, CA
Live Stream: Fubo (free trial)

Live Updates

12:18 AM ET
Heliot Ramos grounds out to second base, José Fermín to Alec Burleson.
12:16 AM ET
Wilmer Flores called out on strikes.
12:14 AM ET
Wilmer Flores pinch-hitting for Drew Gilbert.
12:13 AM ET
Jerar Encarnación grounds out to shallow infield, José Fermín to Alec Burleson.
12:11 AM ET
JoJo Romero (P) replaces Kyle Leahy (P).
12:10 AM ET
Pedro Pagés grounds out to second base to Rafael Devers.
12:09 AM ET
Thomas Saggese strikes out swinging.
12:08 AM ET
Nolan Arenado strikes out swinging.
12:05 AM ET
Joel Peguero (P) replaces Matt Gage (P).
12:05 AM ET
Christian Koss remains in the game as DH.
12:04 AM ET
Patrick Bailey lines out to deep left field to Lars Nootbaar.
12:02 AM ET
Casey Schmitt strikes out swinging.
12:00 AM ET
Christian Koss pinch-running for Bryce Eldridge.
12:00 AM ET
Bryce Eldridge walks.
11:58 PM ET
Matt Chapman grounds out to shortstop, Thomas Saggese to Alec Burleson.
11:55 PM ET
Kyle Leahy (P) replaces John King (P).
11:54 PM ET
Alec Burleson grounds out to second base, Rafael Devers to Matt Gage.
11:54 PM ET
Iván Herrera is intentionally walked.
11:53 PM ET
Lars Nootbaar strikes out swinging.
11:51 PM ET
Victor Scott out on a sacrifice bunt to shallow infield, Patrick Bailey to Rafael Devers. José Fermín to second.
11:49 PM ET
Matt Gage (P) replaces Tristan Beck (P).
11:48 PM ET
José Fermín reaches on error. Throwing error by Matt Chapman.
11:46 PM ET
Willy Adames grounds out to shallow infield, John King to Alec Burleson.
11:44 PM ET
Rafael Devers lines out to shallow infield to John King.
11:42 PM ET
John King (P) replaces Ryan Fernandez (P).
11:41 PM ET
Heliot Ramos grounds out to third base, Nolan Arenado to Alec Burleson.
11:39 PM ET
Jordan Walker flies out to center field to Drew Gilbert.
11:37 PM ET
Pedro Pagés doubles to deep center field.
11:37 PM ET
Thomas Saggese flies out to deep center field to Drew Gilbert.
11:36 PM ET
Nolan Arenado strikes out swinging.
11:36 PM ET
Nolan Arenado strikes out swinging.
11:33 PM ET
Drew Gilbert grounds out to shallow infield, Nolan Arenado to Alec Burleson.
11:32 PM ET
Jerar Encarnación strikes out swinging.
11:31 PM ET
Patrick Bailey singles to shallow left field, tagged out at second, Lars Nootbaar to José Fermín.
11:28 PM ET
Ryan Fernandez (P) replaces Michael McGreevy (P).
11:27 PM ET
Alec Burleson strikes out swinging.
11:26 PM ET
Iván Herrera hits into a force out to third base. Lars Nootbaar out at second.
11:25 PM ET
Lars Nootbaar walks.
11:24 PM ET
Victor Scott lines out to second base to Casey Schmitt.
11:21 PM ET
Casey Schmitt grounds out to shortstop, Thomas Saggese to Alec Burleson.
11:21 PM ET
Bryce Eldridge walks.
11:19 PM ET
Matt Chapman lines out to deep left field to Lars Nootbaar.
11:18 PM ET
Willy Adames flies out to deep center field to Victor Scott.
11:18 PM ET
Rafael Devers homers to center field.
11:14 PM ET
José Fermín called out on strikes.
11:12 PM ET
Jordan Walker hits into a force out to shallow infield. Pedro Pagés out at second. Nolan Arenado scores.
11:11 PM ET
Tristan Beck (P) replaces Justin Verlander (P).
11:10 PM ET
Pedro Pagés hits into a force out to shallow infield. Nolan Arenado to third. Alec Burleson scores. Fielding error by Casey Schmitt.
11:08 PM ET
Thomas Saggese flies out to right center field to Jerar Encarnación.
11:07 PM ET
Nolan Arenado doubles to left field. Alec Burleson to third.
11:05 PM ET
Alec Burleson singles to shallow infield.
11:03 PM ET
Iván Herrera homers to center field. Lars Nootbaar scores.
11:02 PM ET
Lars Nootbaar singles to deep right field.
10:59 PM ET
Heliot Ramos singles to right field, tagged out at second, Jordan Walker to Alec Burleson to José Fermín. Drew Gilbert to third. Patrick Bailey scores. Casey Schmitt scores.
10:57 PM ET
Drew Gilbert walks. Patrick Bailey to second.
10:55 PM ET
Jerar Encarnación strikes out swinging.
10:52 PM ET
Patrick Bailey singles to center field. Casey Schmitt to third. Matt Chapman scores.
10:49 PM ET
Casey Schmitt singles to shallow center field. Matt Chapman to third.
10:48 PM ET
Bryce Eldridge flies out to center field to Victor Scott.
10:46 PM ET
Matt Chapman singles to center field.
10:44 PM ET
Victor Scott grounds out to shallow infield, Justin Verlander to Rafael Devers.
10:43 PM ET
José Fermín doubles to deep left center field. Jordan Walker scores.
10:41 PM ET
Jordan Walker walks.
10:38 PM ET
Pedro Pagés strikes out swinging.
10:36 PM ET
Thomas Saggese lines out to deep right field to Jerar Encarnación.
10:33 PM ET
Willy Adames grounds out to shallow infield, Michael McGreevy to Alec Burleson.
10:30 PM ET
Rafael Devers walks.
10:28 PM ET
Heliot Ramos strikes out swinging.
10:26 PM ET
Drew Gilbert grounds out to second base, José Fermín to Alec Burleson.
10:22 PM ET
Nolan Arenado lines out to left field to Heliot Ramos.
10:20 PM ET
Alec Burleson singles to right field. Iván Herrera to third. José Fermín scores.
10:17 PM ET
Iván Herrera walks.
10:15 PM ET
Lars Nootbaar strikes out swinging.
10:13 PM ET
Victor Scott out on a sacrifice bunt to shallow infield, Matt Chapman to Rafael Devers. José Fermín to third.
10:12 PM ET
José Fermín doubles to left field.
10:09 PM ET
Jerar Encarnación grounds out to third base, Nolan Arenado to Alec Burleson.
10:08 PM ET
Patrick Bailey grounds out to second base to Alec Burleson.
10:06 PM ET
Casey Schmitt grounds out to shallow infield, Nolan Arenado to Alec Burleson.
10:03 PM ET
Jordan Walker hits into a force out to shallow infield, tagged out at second, Matt Chapman to Willy Adames to Patrick Bailey to Casey Schmitt. Thomas Saggese out at home.
10:01 PM ET
Pedro Pagés grounds out to shallow infield, Justin Verlander to Rafael Devers. Thomas Saggese to third.
10:00 PM ET
Thomas Saggese doubles to third base.
9:57 PM ET
Bryce Eldridge grounds out to second base, José Fermín to Alec Burleson.
9:55 PM ET
Matt Chapman reaches on error. Throwing error by Nolan Arenado.
9:54 PM ET
Willy Adames lines out to deep left field to Lars Nootbaar.
9:53 PM ET
Rafael Devers flies out to deep right field to Jordan Walker.
9:52 PM ET
Heliot Ramos homers to center field.
9:49 PM ET
Nolan Arenado strikes out swinging.
9:48 PM ET
Alec Burleson singles to center field.
9:47 PM ET
Iván Herrera grounds out to second base, Justin Verlander to Casey Schmitt to Rafael Devers.
9:46 PM ET
Lars Nootbaar lines out to center field to Drew Gilbert.

San Francisco Giants Team Statistics and Rankings

Win-Loss Record: 77-79
Home Record: 38-37
Away Record: 39-42
Division Record: 16-12
Streak: 1 Win streak
Winning Percentage: .494

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St. Louis Cardinals Team Statistics and Rankings

Win-Loss Record: 76-80
Home Record: 44-37
Away Record: 32-43
Division Record: 24-25
Streak: 1 Win streak
Winning Percentage: .487

Stat Leaders

San Francisco Giants (77-79, #4 in division)

Batting Average Leader: Dominic Smith, 0.284
RBI Leader: Willy Adames, 83 RBI
Home Run Leader: Willy Adames, 28 HR
Runs Leader: Willy Adames, 90 Runs
Hits Leader: Heliot Ramos, 152 Hits
Stolen Bases Leader: Willy Adames, 11 SB
ERA Leader: Erik Miller, 1.50 ERA
Strikeout Leader: Logan Webb, 211 K
Wins Leader: Logan Webb, 14 W
Saves Leader: Ryan Walker, 16 SV

St. Louis Cardinals (76-80, #4 in division)

Batting Average Leader: José Fermín, 0.300
RBI Leader: Willson Contreras, 80 RBI
Home Run Leader: Willson Contreras, 20 HR
Runs Leader: Masyn Winn, 72 Runs
Hits Leader: Alec Burleson, 138 Hits
Stolen Bases Leader: Victor Scott II, 33 SB
ERA Leader: Riley O’Brien, 1.97 ERA
Strikeout Leader: Sonny Gray, 194 K
Wins Leader: Sonny Gray, 14 W
Saves Leader: Ryan Helsley, 21 SV

San Francisco Giants Injury Report

Randy Rodríguez – Elbow (D60) – The San Francisco Giants transferred RHP Randy Rodríguez from the 15-day injured list to the 60-day injured list with a right elbow sprain.
Dominic Smith – Hamstring (D10) – The San Francisco Giants placed INF Dominic Smith on the 10-day injured list with a right hamstring strain.
Landen Roupp – Knee (D15) – The San Francisco Giants placed RHP Landen Roupp on the 15-day injured list due to a left knee inflammation.
Tom Murphy – Back (D60) – The San Francisco Giants placed C Tom Murphy on the 60-day injured list due to mid-back disc herniation.
Carson Whisenhunt – Back (D15) – The San Francisco Giants placed LHP Carson Whisenhunt on the 15-day injured list with a back strain.
Erik Miller – Elbow (D60) – The San Francisco Giants transferred LHP Erik Miller from the 15-day injured list to the 60-day injured list with a left elbow sprain.

St. Louis Cardinals Injury Report

Willson Contreras – Shoulder (D10) – The St. Louis Cardinals placed INF Willson Contreras on the 10-day injured list with right shoulder strain.
Zack Thompson – Lat (D60) – The St. Louis Cardinals transferred LHP Zack Thompson from the 15-day injured list to the 60-day injured list with a tear in the left side lat muscle.
Masyn Winn – Meniscus (D10) – The St. Louis Cardinals placed INF Masyn Winn on the 10-day injured list with a torn meniscus in the right knee.
Nolan Gorman – Undisclosed (Day-to-Day) – Gorman was scratched from Sunday’s (Sep. 21) game against the Brewers with an undisclosed injury.

San Francisco Giants Upcoming 2025 Schedule

September 22, 2025 vs St. Louis Cardinals
September 23, 2025 vs St. Louis Cardinals
September 24, 2025 vs St. Louis Cardinals
September 26, 2025 vs Colorado Rockies
September 27, 2025 vs Colorado Rockies
September 28, 2025 vs Colorado Rockies

St. Louis Cardinals Upcoming 2025 Schedule

September 22, 2025 at San Francisco Giants
September 23, 2025 at San Francisco Giants
September 24, 2025 at San Francisco Giants
September 26, 2025 at Chicago Cubs
September 27, 2025 at Chicago Cubs
September 28, 2025 at Chicago Cubs

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