Arizona Cardinals at San Francisco 49ers – Where to Watch, Stream Info, TV Channel, and Live Updates (September 21, 2025)

The Arizona Cardinals and San Francisco 49ers both enter this matchup with perfect 2-0 records, setting the stage for a competitive clash. The 49ers currently rank #2 in the conference and #1 in their division, showcasing a balanced offensive attack that averages 364.0 total yards per game, including 266.0 through the air. Defensively, they have allowed an average of 268.5 yards per game, contributing to a points allowed average of 17.0.

On the other side, the Cardinals rank #5 in the conference and #2 in their division. They have demonstrated a strong rushing game, averaging 114.0 yards per game, while their defense has allowed 333.5 yards per game. Both teams are riding two-game winning streaks, making this an intriguing early-season matchup.

Arizona Cardinals at San Francisco 49ers Game Information

Game Date: September 21, 2025
Game Time: 04:25 PM ET
TV Channel: FOX
Location: Levi’s Stadium, Santa Clara, CA
Live Stream: Fubo (free trial)

San Francisco 49ers Team Statistics and Rankings

Win-Loss Record: 2-0
Rankings: #2 in Conference, #1 in Division
Home/Away Records: 0-0 at home
Conference Record: 2-0
Division Record: 1-0
Streak: Won 2

San Francisco 49ers Offensive Statistics

Total Offense: 728 yards (Avg. 364.0 yards per game)
Passing Offense: 532 yards (Avg. 266.0 yards per game)
Rushing Offense: 196 yards (Avg. 98.0 yards per game)
Points Scored: 43 points (Avg. 21.5 points per game)
Efficiency Stats: Red Zone: 57.1% (4/7) | Third Down: 51.7% (15/29)

San Francisco 49ers Defensive Statistics

Total Defense: 537 yards (Avg. 268.5 yards per game)
Passing Defense: 332 yards (Avg. 166.0 yards per game)
Rushing Defense: 205 yards (Avg. 102.5 yards per game)
Points Allowed: 34 points (Avg. 17.0 points per game)
Advanced Defensive Stats: Fourth Down Stops: 1 | Three & Outs Forced: 7 | QB Hurries: 3

San Francisco 49ers Individual Stat Leaders

Passing: Mac Jones, 26 Completions/39 Attempts (66.7%), 279 Yards, 3 Touchdowns, 0 Interceptions
Rushing: Christian McCaffrey, 35 Attempts, 124 Yards (3.5 avg), 0 Touchdowns
Receiving: Ricky Pearsall, 8 Receptions, 164 Yards, 0 Touchdowns
Tackles: Fred Warner, 19 Tackles (11 solo, 8 assists)
Sacks: Nick Bosa, 2 Sacks

Arizona Cardinals Team Statistics and Rankings

Win-Loss Record: 2-0
Rankings: #5 in Conference, #2 in Division
Home/Away Records: 1-0 at home
Conference Record: 2-0
Division Record: 0-0
Streak: Won 2

Arizona Cardinals Offensive Statistics

Total Offense: 569 yards (Avg. 284.5 yards per game)
Passing Offense: 341 yards (Avg. 170.5 yards per game)
Rushing Offense: 228 yards (Avg. 114.0 yards per game)
Points Scored: 47 points (Avg. 23.5 points per game)
Efficiency Stats: Red Zone: 57.1% (4/7) | Third Down: 40.9% (9/22)

Arizona Cardinals Defensive Statistics

Total Defense: 667 yards (Avg. 333.5 yards per game)
Passing Defense: 511 yards (Avg. 255.5 yards per game)
Rushing Defense: 156 yards (Avg. 78.0 yards per game)
Points Allowed: 35 points (Avg. 17.5 points per game)
Advanced Defensive Stats: Fourth Down Stops: 2 | Three & Outs Forced: 3 | QB Hurries: 7 | Batted Passes: 1

Arizona Cardinals Individual Stat Leaders

Passing: Kyler Murray, 38 Completions/54 Attempts (70.4%), 383 Yards, 3 Touchdowns, 1 Interceptions
Rushing: Trey Benson, 11 Attempts, 83 Yards (7.5 avg), 0 Touchdowns
Receiving: Trey McBride, 12 Receptions, 139 Yards, 0 Touchdowns
Tackles: Jalen Thompson, 18 Tackles (10 solo, 8 assists)
Sacks: Calais Campbell, 2 Sacks

San Francisco 49ers Injury Report

Connor Colby – Groin (Limited Participation In Practice)
Nick Bosa – Rest (Full Participation In Practice)
Brock Purdy – Shoulder (Limited Participation In Practice)
Jordan James – Finger (Full Participation In Practice)
Yetur Gross-Matos – Knee (Did Not Participate In Practice)
Kyle Juszczyk – Concussion (Full Participation In Practice)
Spencer Burford – Knee (Did Not Participate In Practice)
Siran Neal – Concussion (Full Participation In Practice)
Trent Williams – Knee (Full Participation In Practice)
Jauan Jennings – Ankle (Did Not Participate In Practice)
Jordan Watkins – Calf (Did Not Participate In Practice)
Christian McCaffrey – Calf (Full Participation In Practice)

Arizona Cardinals Injury Report

Calais Campbell – NIR-Rest (Did Not Participate In Practice)
Will Johnson – Groin (Did Not Participate In Practice)
Max Melton – Knee (Limited Participation In Practice)
Tip Reiman – Foot (Limited Participation In Practice)
Cody Simon – Concussion (Full Participation In Practice)
Kelvin Beachum – Rest (Full Participation In Practice)
Will Hernandez – Knee (Limited Participation In Practice)
Paris Johnson Jr. – Knee (Limited Participation In Practice)
Dante Stills – Elbow (Full Participation In Practice)

San Francisco 49ers Upcoming 2025 Schedule

September 21, 2025 vs Arizona Cardinals
September 28, 2025 vs Jacksonville Jaguars
October 02, 2025 at Los Angeles Rams
October 12, 2025 at Tampa Bay Buccaneers
October 19, 2025 vs Atlanta Falcons
October 26, 2025 at Houston Texans
November 02, 2025 at New York Giants
November 09, 2025 vs Los Angeles Rams
November 16, 2025 at Arizona Cardinals
November 24, 2025 vs Carolina Panthers

Arizona Cardinals Upcoming 2025 Schedule

September 21, 2025 at San Francisco 49ers
September 25, 2025 vs Seattle Seahawks
October 05, 2025 vs Tennessee Titans
October 12, 2025 at Indianapolis Colts
October 19, 2025 vs Green Bay Packers
November 03, 2025 at Dallas Cowboys
November 09, 2025 at Seattle Seahawks
November 16, 2025 vs San Francisco 49ers
November 23, 2025 vs Jacksonville Jaguars
November 30, 2025 at Tampa Bay Buccaneers