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How to Watch Cardinals at 49ers: Stream NFL Live, TV Channel

September 21, 2025 by Ben Macaluso
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Both the Arizona Cardinals and San Francisco 49ers look to stay undefeated in this division rivalry late Sunday afternoon.

The San Francisco 49ers have to be feeling good for their home opener, looking to improve to 3-0 on the season, when they host the Arizona Cardinals on Sunday for this NFC West rivalry. The 49ers would like their starting QB back, but Brock Purdy is listed as questionable with a toe injury. Since Joe Burrow will be out for three months with turf toe, this is nothing to take lightly. Purdy says he is day-to-day with the injury, but head coach Kyle Shanahan said it is highly unlikely that he will play today against the Cardinals. The good news for San Francisco is that backup Mac Jones looked strong in relief last week against the New Orleans Saints. Competing against the likes of Kyler Murray will be another story. The Cardinals aren’t going anywhere and will be a tough out, as they enter this game with a 2-0 record as well. But this will easily be their toughest test of the season, with those wins coming against the Carolina Panthers and Saints who both have yet to earn a win this season. This game will be considered a coin flip, with the 49ers holding on to just a -1.5-point spread.

How to Watch Arizona Cardinals at San Francisco 49ers Today:

Game Date: Sunday, Sept. 21, 2025

Game Time: 4:25 p.m. ET

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TV: FOX

Location: Levi’s Stadium

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The 49ers beat the Saints last week 26-21 to remain undefeated on the season. Jones showed flashes of what brought him to the Pro Bowl in his rookie campaign in New England. The San Francisco backup went 26-39 with three touchdowns and 279 passing yards in the victory. The 49ers never trailed in the game, but it also gave up three touchdowns from Spencer Rattler who has yet to earn a victory in eight starts in the NFL. It’s the formula that the 49ers were looking for, but their defense will have to expect a lot more from Arizona this afternoon.

The Cardinals are coming off a 27-22 win over the Panthers. Arizona was kind of in the same boat that San Francisco was in. Bryce Young threw for 325 yards with three touchdowns and an interception. He outplayed Murray, who had 220 yards with a touchdown and a pick. The Cardinals did benefit though from getting up 27-3, before letting up 19 unanswered points. Arizona can’t afford to let up on the gas today, especially on the road. This is the first big test for the Cards this season.

What Time Is The NFL Between Arizona and San Francisco?

The Arizona Cardinals at San Francisco 49ers game will take place on Sunday, Sept. 21, 2025 at 4:25 p.m. ET. Tune in and catch some furious football action.

What Channel Is The Arizona Cardinals at San Francisco 49ers Game On?

Looking to watch this game? Fans can tune into FOX to see the action. Make sure you subscribe to Fubo now to watch this matchup, as well as numerous other sports leagues.

Watch the Arizona Cardinals at San Francisco 49ers game on Fubo: Start watching now!

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