Jacksonville Jaguars at San Francisco 49ers – Where to Watch, Stream Info, TV Channel, and Live Updates (September 28, 2025)

The Jacksonville Jaguars, currently holding a 2-1 record, will face the undefeated San Francisco 49ers, who boast a perfect 3-0 mark, in a highly anticipated matchup. The 49ers have shown strong performance at home, winning their only game at Levi’s Stadium this season, while the Jaguars are coming off a recent victory, looking to build momentum.

San Francisco leads the league with a robust offensive output, averaging 361.0 total yards per game, while their defense has been equally impressive, allowing just 265.7 yards per game. In contrast, Jacksonville has averaged 356.3 total yards per game, with a notable rushing attack averaging 141.7 yards per game. This clash of styles promises to be a compelling contest as both teams aim to solidify their standings in their respective conferences.

Jacksonville Jaguars at San Francisco 49ers Game Information

Game Date: September 28, 2025
Game Time: 04:05 PM ET
TV Channel: FOX
Location: Levi’s Stadium, Santa Clara, CA
Live Stream: Fubo (free trial)

San Francisco 49ers Team Statistics and Rankings

Win-Loss Record: 3-0
Rankings: #1 in Conference, #1 in Division
Home/Away Records: 1-0 at home
Conference Record: 3-0
Division Record: 2-0
Streak: Won 3

San Francisco 49ers Offensive Statistics

Total Offense: 1083 yards (Avg. 361.0 yards per game)
Passing Offense: 814 yards (Avg. 271.3 yards per game)
Rushing Offense: 269 yards (Avg. 89.7 yards per game)
Points Scored: 59 points (Avg. 19.7 points per game)
Efficiency Stats: Red Zone: 45.5% (5/11) | Third Down: 43.6% (17/39)

San Francisco 49ers Defensive Statistics

Total Defense: 797 yards (Avg. 265.7 yards per game)
Passing Defense: 486 yards (Avg. 162.0 yards per game)
Rushing Defense: 311 yards (Avg. 103.7 yards per game)
Points Allowed: 49 points (Avg. 16.3 points per game)
Advanced Defensive Stats: Fourth Down Stops: 1 | Three & Outs Forced: 10 | QB Hurries: 4 | Batted Passes: 2

San Francisco 49ers Individual Stat Leaders

Passing: Mac Jones, 53 Completions/80 Attempts (66.2%), 563 Yards, 4 Touchdowns, 1 Interceptions
Rushing: Christian McCaffrey, 52 Attempts, 176 Yards (3.4 avg), 0 Touchdowns
Receiving: Ricky Pearsall, 16 Receptions, 281 Yards, 0 Touchdowns
Tackles: Fred Warner, 30 Tackles (16 solo, 14 assists)
Sacks: Bryce Huff, 2 Sacks

Jacksonville Jaguars Team Statistics and Rankings

Win-Loss Record: 2-1
Rankings: #6 in Conference, #2 in Division
Home/Away Records: 2-0 at home
Conference Record: 1-1
Division Record: 1-0
Streak: Won 1

Jacksonville Jaguars Offensive Statistics

Total Offense: 1069 yards (Avg. 356.3 yards per game)
Passing Offense: 644 yards (Avg. 214.7 yards per game)
Rushing Offense: 425 yards (Avg. 141.7 yards per game)
Points Scored: 70 points (Avg. 23.3 points per game)
Efficiency Stats: Red Zone: 50.0% (7/14) | Third Down: 37.5% (15/40)

Jacksonville Jaguars Defensive Statistics

Total Defense: 876 yards (Avg. 292.0 yards per game)
Passing Defense: 628 yards (Avg. 209.3 yards per game)
Rushing Defense: 248 yards (Avg. 82.7 yards per game)
Points Allowed: 51 points (Avg. 17.0 points per game)
Advanced Defensive Stats: Fourth Down Stops: 2 | Three & Outs Forced: 8 | QB Hurries: 7 | Batted Passes: 5

Jacksonville Jaguars Individual Stat Leaders

Passing: Trevor Lawrence, 63 Completions/113 Attempts (55.8%), 671 Yards, 4 Touchdowns, 4 Interceptions
Rushing: Travis Etienne Jr., 46 Attempts, 270 Yards (5.9 avg), 1 Touchdowns
Receiving: Brenton Strange, 13 Receptions, 137 Yards, 0 Touchdowns
Tackles: Foyesade Oluokun, 23 Tackles (13 solo, 10 assists)
Sacks: Travon Walker, 2 Sacks
Interceptions: Jourdan Lewis, 2 Interceptions

San Francisco 49ers Injury Report

Jordan Watkins – Calf (Did Not Participate In Practice)
Mac Jones – Knee (Limited Participation In Practice)
C.J. West – Thumb (Did Not Participate In Practice)
Deommodore Lenoir – Illness (Full Participation In Practice)
Mykel Williams – Wrist (Full Participation In Practice)
Trent Williams – NIR-Rest (Full Participation In Practice)
Christian McCaffrey – NIR-Rest (Full Participation In Practice)
Ricky Pearsall – Knee (Limited Participation In Practice)
Brock Purdy – Shoulder (Full Participation In Practice)
Connor Colby – Groin (Limited Participation In Practice)
Kalia Davis – Ankle (Full Participation In Practice)
Renardo Green – Neck (Did Not Participate In Practice)
Yetur Gross-Matos – Knee (Did Not Participate In Practice)
Jauan Jennings – Ankle (Limited Participation In Practice)

Jacksonville Jaguars Injury Report

Dyami Brown – Shoulder (Limited Participation In Practice)
Brian Thomas Jr. – Wrist (Full Participation In Practice)
Ezra Cleveland – Ankle (Limited Participation In Practice)
Patrick Mekari – Elbow (Limited Participation In Practice)
Wyatt Milum – Knee (Limited Participation In Practice)
Yasir Abdullah – Hamstring (Limited Participation In Practice)
Bhayshul Tuten – Shoulder (Full Participation In Practice)

San Francisco 49ers Upcoming 2025 Schedule

September 28, 2025 vs Jacksonville Jaguars
October 02, 2025 at Los Angeles Rams
October 12, 2025 at Tampa Bay Buccaneers
October 19, 2025 vs Atlanta Falcons
October 26, 2025 at Houston Texans
November 02, 2025 at New York Giants
November 09, 2025 vs Los Angeles Rams
November 16, 2025 at Arizona Cardinals
November 24, 2025 vs Carolina Panthers
November 30, 2025 at Cleveland Browns

Jacksonville Jaguars Upcoming 2025 Schedule

September 28, 2025 at San Francisco 49ers
October 06, 2025 vs Kansas City Chiefs
October 12, 2025 vs Seattle Seahawks
October 19, 2025 vs Los Angeles Rams
November 02, 2025 at Las Vegas Raiders
November 09, 2025 at Houston Texans
November 16, 2025 vs Los Angeles Chargers
November 23, 2025 at Arizona Cardinals
November 30, 2025 at Tennessee Titans
December 07, 2025 vs Indianapolis Colts