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House and his team wrestle with an ethical dilemma when an elderly patient demands that they stop treating him and help him to die.
Dr. House takes the case of an autistic 10-year-old who screams for no apparent reason, then House refuses to use his office after Cuddy makes a minor change.
House treats a young married couple with similar symptoms, but they are shocked by the cause of the illness; a walk-in patient, David Morse, stands up to House.
After being found in a coma at his apartment, a 600-pound man is admitted to the hospital; House spends the night in jail after being arrested for a number of violations.
When the son of a man in a vegetative state starts going into a coma, the vegetative man is reawakened chemically by House, who hopes to get some clues to the son's problems.
House challenges his co-workers to correctly diagnose the ailment of an 18-year-old heart-attack patient, Patrick Fugit.
House takes the divorced parents of a young patient to court when their bickering prevents a decision on her treatment.