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13 Alabama at Florida State
NCAAFThe Seminoles put 2024 in the rearview during this opener against the No. 8 Crimson Tide. Florida State went a forgettable 2-10 last year. Alabama turns to Ty Simpson at quarterback after Jalen Milroe was drafted by the NFL's Seattle Seahawks.
North Carolina at Syracuse
NCAAFThe Orange host the Tar Heels for some Friday night frights at the JMA Wireless Dome. Both teams have been spooked of late, losing four in a row. North Carolina has haunted Syracuse across the past two meetings, outscoring the Orange 71-13.
Georgia Tech at NC State
NCAAFThe Wolfpack (4-4, 1-3 ACC) field a challenge from the undefeated No. 8 Yellow Jackets (8-0, 5-0) in Week 10. Georgia Tech picked up a 30-29 home victory over NC State last season. The Yellow Jackets are 8-0 for the first time since 1966.
North Carolina at TCU
NCAAFThe TCU Horned Frogs and North Carolina Tar Heels clash at Aviva Stadium in Dublin for the Aer Lingus Classic. Both teams play their first game after TCU beat USC 30-27 and North Carolina fell 42-19 to NC State to close out last season.
NC State at Virginia
NCAAFThe Virginia Cavaliers host the NC State Wolfpack at Scott Stadium in Charlottesville for a regular-season game. Both teams play their first game after Virginia beat Missouri 13-7 and NC State defeated Memphis 31-7 to end last season.
Hawaii at Stanford
NCAAFThe Stanford Cardinal host the Hawaii Rainbow Warriors at Stanford Stadium in Stanford, California. Both teams play their first game after Stanford fell 49-20 to Notre Dame and Hawai'i beat California 35-31 to close out the previous season.
Virginia Tech at South Carolina
NCAAFThe No. 13 Gamecocks begin a season of heightened expectations by taking on the Hokies. South Carolina is ranked in the AP's preseason poll for the first time since 2014, and looks to build around promising sophomore quarterback LaNorris Sellers.
Akron at Wake Forest
NCAAFThe Zips and the Demon Deacons meet for an interconference game at Allegacy Federal Credit Union Stadium. Akron won against Bowling Green 19-16 in their final game in 2025. Wake Forest defeated Mississippi State 43-29 in their last 2025 game.
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7 Miami at 1 Ohio State
NCAAFThe No. 10 Miami Hurricanes face the No. 2 Ohio State Buckeyes at AT&T Stadium. This is a high-stakes College Football Playoff Quarterfinal matchup. Miami advanced after a gritty 10-3 road upset over No. 7 Texas A&M in the CFP First Round.
7 Miami at 9 Ole Miss
NCAAFNo. 6 Ole Miss faces No. 10 Miami in the Fiesta Bowl at State Farm Stadium for a spot in the College Football Playoff semifinals. The Rebels seek an eighth straight win behind Kewan Lacy (23 TDs), while the Hurricanes lean on QB Carson Beck (27 TDs).
Duke at Virginia
NCAAFThe No. 17 Cavaliers (10-2) and Blue Devils (7-5) compete for the ACC championship. Virginia defeated Duke 34-17 in November. Cavaliers senior J'Mari Taylor has rushed for 14 touchdowns. Blue Devils sophomore Darian Mensah boasts 28 touchdown passes.
24 Louisville at 7 Miami
NCAAFThe Cardinals (4-1, 1-1 ACC) try to bounce back against a tough foe in the No. 2 Hurricanes (5-0, 1-0). Louisville dropped its first game of the season in a 30-27 overtime decision versus Virginia on Oct. 4. Miami defeated Louisville 52-45 last year.
7 Miami at 6 Indiana
NCAAFTop-seeded Indiana (15-0) faces No. 10 Miami in the CFP National Championship. After routing Oregon in the semifinals, the Hoosiers look to complete a perfect season against a Hurricanes team that has a 13-2 overall scoring record.
Duke at Clemson
NCAAFThe Tigers (3-4, 2-3 ACC) and Blue Devils (4-3, 3-1) return from the bye. In 2023, Duke snapped a five-game series slide with its first victory over Clemson since 2004. Duke's three-game win streak was snapped by undefeated Georgia Tech on Oct. 18.
Clemson at Georgia Tech
NCAAFThe No. 12 Tigers seek a 10th straight win over the Yellow Jackets in this match from Bobby Dodd Stadium. Clemson doubled up Georgia Tech 42-21 behind four TD passes from Cade Klubnik on Nov. 11, 2023. Georgia Tech leads the all-time series 51-36-2.
13 Alabama at Florida State
NCAAFThe Seminoles put 2024 in the rearview during this opener against the No. 8 Crimson Tide. Florida State went a forgettable 2-10 last year. Alabama turns to Ty Simpson at quarterback after Jalen Milroe was drafted by the NFL's Seattle Seahawks.