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California at Stanford
NCAAFThe Cardinal host the Golden Bears. Stanford leads the all-time series 65-51-11, but California has won four straight meetings after rallying to keep the streak alive in 2024. Cal stunned then-No. 15 Louisville in overtime prior to its bye Nov. 8.
Stanford at Virginia
NCAAFThe Cavaliers (2-1, 0-0) kick off their ACC slate for 2025 by meeting the Cardinal (1-2, 1-0) for the first time. Stanford began its league schedule with a 30-20 home win over Boston College on Sept. 13 after an 0-2 start on the road.
Michigan State at Boston College
NCAAFThe Spartans visit the Eagles. Michigan State is off to its second 3-0 start in four years after a 40-0 masterclass versus Prairie View A&M on Sept. 14. Boston College suffered its first loss in the Bill O'Brien era, 27-21 to then-No. 6 Missouri.
Florida State at Virginia
NCAAFThe No. 8 Seminoles and Cavaliers meet for the first time since 2019. Florida State has outscored its foes 174-30 in 2025. Chandler Morris (UVA) passed for 380 yards and created five touchdowns in a 48-20 win over Stanford in Week 4.
Virginia at North Carolina
NCAAFThe No. 16 Cavaliers (6-1, 3-0 ACC) visit Bill Belichick and the Tar Heels (2-4, 0-2). The teams have combined to average 68 points over the last seven meetings after North Carolina prevailed 41-14 in 2024. Virginia has won its last five games.
Virginia at California
NCAAFThe No. 15 Cavaliers play the Golden Bears for the first time. Virginia has won six in a row, with three of those victories coming in overtime after outlasting North Carolina 17-16 on Oct. 25. California comes off a double-OT loss at Virginia Tech.
Wake Forest at Virginia
NCAAFThe No. 14 Cavaliers eye an eighth straight win as they host the Demon Deacons. Virginia ended a five-game series slide with a win last year, its first over Wake Forest since 2007. Demond Claiborne (WAKE) topped 100 yards from scrimmage with two TDs.
Virginia at Duke
NCAAFThe No. 19 Cavaliers (8-2, 5-1) try to maintain their recent mastery of the Blue Devils (5-4, 4-1) in a clash of ACC contenders. Virginia has won eight of the last nine meetings. UVA comes off a 16-9 upset loss at home against Wake Forest.
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Boston College at Syracuse
NCAAFThe Orange (3-8, 1-6 ACC) and Eagles (1-10, 0-7) close out the 2025 campaign with this tilt. Boston College has won two straight meetings, and four of its last five visits to Syracuse. The programs have lost a combined 17 consecutive outings.
Pittsburgh at Georgia Tech
NCAAFThe Panthers line up against the No. 16 Yellow Jackets. Georgia Tech bounced back from its first loss of the season by outlasting Boston College, 36-34 on Nov. 15. Pittsburgh had a five-game win streak snapped in a loss to then-No. 9 Notre Dame.
Florida State at Florida
NCAAFThe Seminoles (5-6) try to clinch bowl eligibility as they visit the Gators (3-8) in a Florida Cup clash. Florida won four of the last six Sunshine Showdown meetings, but Florida State picked up a 24-15 victory in its last visit to The Swamp in 2023.
SMU at Clemson
NCAAFThe Mustangs (4-2, 2-0 ACC) visit the Tigers (3-3, 2-2). Clemson earned a record 22nd ACC title by beating SMU 34-31 on a buzzer-beating field goal Dec. 7, 2024. Bryant Wesco Jr. (CLEM) is among the nation's leaders with 537 receiving yards in 2025.
Miami at SMU
NCAAFThe No. 10 Hurricanes (6-1, 2-1) head to Big D for an ACC affair with the Mustangs (5-3, 3-1). SMU won the only prior meeting, 7-3 in 1965. Miami bounced back from a stunning setback against Louisville with a 42-7 victory over Stanford last week.