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Reporter Angela (Jennifer Carpenter) and her cameraman Scott (Steve Harris) are doing a story on night-shift firefighters for a reality-TV program. A late-night distress call takes them to a Los Angeles apartment building, where the police are investigating a report of horrific screams. The TV team and emergency workers find an old woman, who suddenly attacks with teeth bared. What's more, Angela and company find that the building has been sealed by CDC workers. Then the attacks really begin.

The Conners celebrate Mark when he makes it on the dean's list at his new magnet school; Jackie continues to navigate her relationship with Neville.

Darlene continues to navigate her breakup with Ben; Dan offers to talk with Aldo's dad when he doesn't approve of Harris and Aldo's relationship.

When a crew of violent eco-terrorists abducts the teenage son of an energy company executive, the team must untangle the kidnappers' twisted motives before carrying out a high-stakes rescue mission; Hondo's involvement in a shooting draws outrage.

Boden takes a big step in the pursuit of a major career decision; Kidd becomes increasingly distrustful of Renee's motives with Severide; Herrmann has trouble bouncing back after a tragedy.

Tim seeks out help from an unlikely person when he finds himself competing in a polo match; Amy is concerned her daughter isn't adjusting well to her new reality; she makes a decision that worries Jack.