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This long-running animated comedy focuses on the eponymous family in the town of Springfield in an unnamed U.S. state. The head of the Simpson family, Homer, is not a typical family man. A nuclear-plant employee, he does his best to lead his family but often finds that they are leading him. The family includes loving, blue-haired matriarch Marge, troublemaking son Bart, overachieving daughter Lisa and baby Maggie. Other Springfield residents include the family's religious neighbor, Ned Flanders, family physician Dr. Hibbert, Moe the bartender and police chief Clancy Wiggum.

When Gloria goes on vacation, Abishola takes charge of the nursing staff, but quickly falls short as the job requires "people skills"; with Abishola busy at the hospital, the Wheelers try to cope with her temporary absence.

When Dottie moves her husband Max's urn into Bob and Abishola's living room, everyone is forced to confront their views on death and the afterlife; Goodwin pits Douglas and Kofo against each other in a battle for Dottie's vacant MaxDot office.

Firehouse 51 bands together to fight a raging fire on the 20th floor of the residential high-rise where Jay and Will Halstead's father lives and has gone missing; in the midst of the chaos, Brett learns unsettling information about her new partner.

A country house in Michigan goes up in flames, leaving a father of five dead, a litany of questions, and a family divided.

In a quiet Texas suburb, the brutal murder of Belinda Temple reveals a presumed burglary to be a cover for a tangled web of infidelity and deceit.

A tenacious, veteran journalist is found murdered outside his Las Vegas home. Was he the victim of an attempted burglary gone wrong or something more sinister?