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Itinerant worker George (Gary Sinise) reflects on the time he spent traveling with Lennie (John Malkovich), a huge childlike man. The two men drift through California during the Great Depression, looking for work. After they find jobs on a ranch, Lennie develops an infatuation with the owner's daughter-in-law (Sherilyn Fenn). However, when George and Lennie are handed an opportunity to own part of the ranch, Lennie's fascination with the beautiful woman threatens to destroy their dreams.
Itinerant worker George (Gary Sinise) reflects on the time he spent traveling with Lennie (John Malkovich), a huge childlike man. The two men drift through California during the Great Depression, looking for work. After they find jobs on a ranch, Lennie develops an infatuation with the owner's daughter-in-law (Sherilyn Fenn). However, when George and Lennie are handed an opportunity to own part of the ranch, Lennie's fascination with the beautiful woman threatens to destroy their dreams.