
Growing up in racially segregated Birmingham, Alabama, during the 1960's, Rene and Mary Elizabeth manage to stick together despite community intolerance of "mixed" friendships. Many years later, following the death of her father, Rene returns home and reunites with Mary Elizabeth. The women realize that despite their career and family differences, they can help each other find happiness.

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Mary Elizabeth gets published; Collier lies about going to work; Rene has misgivings about a case; young M.E. enters the school talent show.
M.E.'s sister (Delta Burke) jolts Collier out of depression and irritates Rene with her prejudice; at a segregated hospital, Catherine insists on medical care for young Rene.
Mary Elizabeth and Collier use Grandma Otis' legacy to start a construction business; Michael continues to stalk Rene; young M.E. and Rene happen upon a KKK meeting.
Collier's business acumen catches Mary Elizabeth off guard; Rene's cousin poses as white; young Rene's celebrated aunt (Jasmine Guy) visits.