
Growing up in racially segregated Birmingham, Alabama, during the 1960's, Rene and Mary Elizabeth manage to stick together despite community intolerance of "mixed" friendships. Many years later, following the death of her father, Rene returns home and reunites with Mary Elizabeth. The women realize that despite their career and family differences, they can help each other find happiness.

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A boy kills another who was threatening him with a gun; Kelly is arrested for drunken driving; young M.E. is jealous of Rene's maturation.
Mary Elizabeth invites Grandma Otis to live with the family; the girls help young Collier fend off bullies.
Rene represents the parents of a child who died from AIDS; Mary Elizabeth tries to bring her and Rene's friends together.
Mary Elizabeth learns she is pregnant; Rene represents a white couple whose black foster child was taken away; Johnny scuffles with the manager after young Rene is refused service at a soda fountain.