
Growing up in racially segregated Birmingham, Alabama, during the 1960's, Rene and Mary Elizabeth manage to stick together despite community intolerance of "mixed" friendships. Many years later, following the death of her father, Rene returns home and reunites with Mary Elizabeth. The women realize that despite their career and family differences, they can help each other find happiness.

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Mary Elizabeth's sister Teresa moves to Birmingham for a fresh start; Rene's mother finds out her ex-boyfriend wiped out her bank account.
Rene prepares to meet Bill's children with some help from Mary Elizabeth; Mary Elizabeth and Collier argue over his birthday party.
Rene represents a man who is to be sterilized against his will; young Rene and M.E. attend a segregated concert.
Rene (Lorraine Toussaint) is sued for malpractice; Mary Elizabeth (Annie Potts) struggles with her daughter's Gothic obsession.