S6, EP4 "In Search of Forgiveness, Not Permission"
Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman; Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial; Dr. Choi clashes with a patient who demands absolute perfection of himself.
S6, EP3 "Do You Know the Way Home?"
Dr. Charles and April team up to take on a mysterious patient in the ED; Dr. Halstead is forced to make a life-or-death decision for one of his trial patients; Dr. Marcel is confronted by his past when a former acquaintance is brought into the ED.
S6, EP2 "Those Things Hidden in Plain Sight"
Goodwin announces a new ED Chief, and the choice doesn't make everyone happy; Dr. Manning takes a stand for her patient and finds herself dealing with the repercussions; Dr. Charles tends to family affairs.
S6, EP1 "When Did We Begin to Change"
The staff adjusts to the new normal of the pandemic; Dr. Choi, Dr. Lanik and April fight on the front lines; Dr. Halstead and Hannah face a troubling reality; Dr. Charles tries to clear the air with his daughter following recent developments.