
Emergency room nurse Jackie Peyton does everything she can to provide her patients with the best care possible while navigating the waters of a crumbling health-care system. But she has a secret that is increasingly difficult to keep from people -- she relies on Vicodin and Adderall to get her through high-stress shifts at a New York hospital, where she isn't above bending the rules to keep things running smoothly in the face of indifferent doctors, penny-pinching bean counters and miles of bureaucratic red tape.

Although struggling financially, Jackie and Kevin refuse an offer of help from O'Hara; Jackie discovers the friendship between Kevin and Eddie.

Jackie dispenses illegal marijuana to a suffering patient; Kevin skips date night to attend a basketball game with Eddie; Zoey believes she is pregnant.

Coop is selected for a marketing campaign; a security guard makes Jackie's secret life more difficult; O'Hara reveals a longtime affair.

Jackie asks Eddie to end his friendship with Kevin; a pharmaceutical company rep serves Jackie's needs; O'Hara's romance heats up.