
Emergency room nurse Jackie Peyton does everything she can to provide her patients with the best care possible while navigating the waters of a crumbling health-care system. But she has a secret that is increasingly difficult to keep from people -- she relies on Vicodin and Adderall to get her through high-stress shifts at a New York hospital, where she isn't above bending the rules to keep things running smoothly in the face of indifferent doctors, penny-pinching bean counters and miles of bureaucratic red tape.

Jackie loses her stash and confesses that she took O'Hara's loan; the hospital struggles while Jackie is on vacation.

After returning to work, Jackie can no longer avoid confrontations.

Jackie's relationships are strained; Akalitus announces that area hospitals have closed; Zoey confesses about her affair.

Eddie wants to tell Kevin the truth; Jackie learns that O'Hara is looking for a new job.