
Emergency room nurse Jackie Peyton does everything she can to provide her patients with the best care possible while navigating the waters of a crumbling health-care system. But she has a secret that is increasingly difficult to keep from people -- she relies on Vicodin and Adderall to get her through high-stress shifts at a New York hospital, where she isn't above bending the rules to keep things running smoothly in the face of indifferent doctors, penny-pinching bean counters and miles of bureaucratic red tape.

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Jackie leaves rehab early and struggles to maintain sobriety; Zoey has second thoughts about her relationship; Eddie tells Jackie he confessed.
Jackie learns that Grace knows the truth about rehab; Cruz docks Jackie's pay for stolen supplies; Jackie asks Charlie to meet her at an AA meeting.
Lonely, Jackie invites Kevin to meet her at a café; a double suicide trauma case comes to the E.R.; Cruz institutes a new dress code; Zoey looks for a new roommate.
Jackie has a dream about Cruz and using; Coop becomes insistent about involvement with O'Hara's child; Zoey questions her feelings for Lenny; O'Hara takes action.