A women's health clinic in Philadelphia is the setting for this drama. While dealing with a number of medical issues, the show often revolves around the conflict between the clinic's directors: one a passionate advocate for patients and the other a more discipline-oriented doctor.

Andy encounters a young woman with amnesia; a pregnant woman refuses to stop using drugs; Andy treats an elderly woman who is addicted to prescription drugs.

Lu cannot decide whether to tell her patients about an experimental antismoking clinical trial; Andy helps a bypass patient weather the side effects of surgery.

Andy and Lu engage in a friendly competition over a spelling bee; Lu helps a mother who suffers from schizophrenia; Andy adjusts to spending the holidays without her daughters.

Andy helps a young foreign princess fix a deformity; Lu treats an elderly woman with Alzheimer's.