A women's health clinic in Philadelphia is the setting for this drama. While dealing with a number of medical issues, the show often revolves around the conflict between the clinic's directors: one a passionate advocate for patients and the other a more discipline-oriented doctor.

Andy and Lu engage in a friendly competition over a spelling bee; Lu helps a mother who suffers from schizophrenia; Andy adjusts to spending the holidays without her daughters.

Andy helps a young foreign princess fix a deformity; Lu treats an elderly woman with Alzheimer's.

Lu finds out her son's friend is being abused by a high-school boyfriend; Lu counsels a woman with HIV; an obese couple desperately want to lose weight.

Lu meets and butts heads with Ben Sanderson; Andy takes on the issue of legal sterilization; a girl becomes ill with E. coli bacteria.