A women's health clinic in Philadelphia is the setting for this drama. While dealing with a number of medical issues, the show often revolves around the conflict between the clinic's directors: one a passionate advocate for patients and the other a more discipline-oriented doctor.

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Andy treats a judge for hearing loss; Lu and Ben's romance blossoms; Peter faces murder charges after a string of elderly deaths.
A breast cancer survivor develops a psychological disorder.
Andy is on probation; Lu's patient needs surgery but wants a faith healer, instead.
The clinic may receive a generous donation if Lu agrees to perform a set of physicals; Andy competes for the vacated position of chief of surgery; Kayla treats a teen's gunshot wound.