
Some of the world's most notorious murders are the subject of "It Takes a Killer," which investigates the crimes from the perspective of the killers, trying to get inside their minds and determine their motives. Leading homicide investigators and experts from such agencies as the FBI and Scotland Yard take a look at the evidence pulled from crime scenes and profile the killer's behavior to try to piece together the details of each murder, explaining when, why and how each criminal committed the crime. For the wannabe detectives watching the show, the experts also reveal how the crime was solved -- which often requires authorities to think like a killer.

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After years of abuse, a high school valedictorian snaps, viciously stabbing his mother in the family's garage and almost gets away with her savage murder, except for some inconsistencies in his alibi that reveal his true plans.
A bizarre lovers' triangle turns lethal and a mother of two suddenly disappears.
The murder of a millionaire doctor's wife sets off a massive manhunt throughout New England; law enforcement quickly locates the suspected killer only to find out he has a history of not only violence but also cross-dressing.
An unemployed teen mom and her new husband concoct a plan to kill an innocent man they meet on Craigslist, resulting in a vicious stabbing that sends shock waves through a small Pennsylvania community.