Conrad contemplates his future; Devon is presented with an amazing career opportunity out of state; Ian is faced with a devastating diagnosis; Kit and Bell celebrate their engagement; Padma receives some highly anticipated news.

A young boy comes into the hospital with a rare disease that leaves his bones incredibly fragile; with his clinical trial officially being declared a success, Devon has some huge decisions to make about the future of his career.

When one of the doctors is shot outside the hospital, the emergency room is put into lockdown; a patient learns he is unable to receive a transplant due to his vaccination status; Devon and Leela try to juggle the new dynamics of their relationship.

Conrad and Cade work with a Medicare patient who sheds some light on the inner workings of the prescription fraud situation; Leela works herself to the brink of exhaustion to avoid having a conversation with Devon.

With Raptor on leave to take care of his mother, the hospital scrambles to stay organized without him; a camping trip leaves a patient with a fatal disease that none of the doctors have seen before; Bell and Kit devise a plan to help their case.