
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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With his diagnostic team gone, House tries to diagnose a young woman who survived an office building collapse; Cuddy puts pressure on House to hire a new team.
House begins interviewing for the open positions on his team and sets the applicants against one another to help treat a woman who has an unusual neurological disorder.
House splits the final ten fellowship candidates into two teams by gender; the teams must treat a man with muscular atrophy and diagnose the cause; at his new hospital, Foreman resorts to house-like behavior to help a patient.
House and the remaining candidates must determine why a 20-year-old cosmetician had a massive seizure and now has hallucinations; Foreman's reputation precedes him as he interviews for a new job; House must narrow the candidates to six.