
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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House and the team treat a ballerina whose lungs collapse during a performance; House is desperate to find a cure for his insomnia.

House is intrigued by a patient whose left brain and right brain operate independently, creating two distinct personalities.

House goes through detox, hoping to stop the hallucinations that torment him; Dr. Nolan refuses to sign the paperwork to reinstate House's license until House participates in his own mental recovery.

House decides to accept treatment from Dr. Nolan in order to get his license reinstated.