
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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A documentary film crew follows House and his team, as they treat a teenager who had a heart attack prior to facial reconstruction; several of the fellowship candidates distract House.
House treats a magician but comes to believe he's faking illness to cover up his own incompetence; he pits the fellows against each other in his version of an immunity challenge.
Under Cuddy's pressure to choose his team, House gives the candidates a case of a former punk rock star who is a drug user; whoever diagnoses the patient is going to have a future as a member of House's team.
As the team runs tests to determine what caused a woman to have sudden paralysis of the hands, the rest of her system begins to shut down; the team participates in a gift exchange with a twist, courtesy of House.