
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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Cameron asks House to accept the case of an environmental activist who collapsed at a protest with mysterious symptoms.
A deaf 14-year-old wrestler suffers from hearing problems during a match, but his mother refuses to okay cochlear implants; House's insomnia proves to be a curse and a blessing.
House and the team treat a ballerina whose lungs collapse during a performance; House is desperate to find a cure for his insomnia.
House is intrigued by a patient whose left brain and right brain operate independently, creating two distinct personalities.