
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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House splits the final ten fellowship candidates into two teams by gender; the teams must treat a man with muscular atrophy and diagnose the cause; at his new hospital, Foreman resorts to house-like behavior to help a patient.
House and the remaining candidates must determine why a 20-year-old cosmetician had a massive seizure and now has hallucinations; Foreman's reputation precedes him as he interviews for a new job; House must narrow the candidates to six.
A victim of a mugging presents with neurological symptoms and begins to mirror the behaviors of his doctors; Foreman joins the new fellows in seeking a diagnosis; Cameron and Chase takes bets on whom House will fire next.
The CIA recruits House to help an agent dying of an unknown illness; Foreman faces resistance from the remaining fellowship candidates when they question his judgment.