
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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Cuddy gives some of her day-to-day responsibilities to Cameron; the team takes on the case of a teacher who collapsed after spitting up blood during a class.

While treating a former cancer researcher who gave up her career to pursue her own personal happiness, House and his staff begin to question their own choices; Thirteen begins to show serious reactions to her experimental treatment.

A housewife on fertility medication visits Princeton Plainsboro Hospital when her inexplicable muscle-flailing causes her to crash her car.

When a young man comes into the hospital severely burned and has unusual blood-test results, House and his team have a difficult challenge.