
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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House and his team have to diagnose a case at a distance when a researcher at a South Pole base is taken ill.
House and the team consider foul play while treating a woman who collapsed at her wedding; Wilson's newly revealed relationship preoccupies House.
House suspects a patient has a bigger problem than the original diagnosis; House and Amber argue about how much time they each get to spend with Wilson; Cuddy demands that House give his team performance reviews.
House takes matters into his own hands; he feels certain that one of the actors on his favorite soap opera is suffering from a serious medical condition; the actor dismisses House's assessment.