
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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Thirteen's date gets ill after a night of partying and House takes on her case; Foreman confronts Thirteen about her self-destructive lifestyle; private investigator Lucas is hot on Wilson's trail.
The team takes on the case of a sleepwalking patient experiencing unexplained blackouts; House discovers that Cuddy is planning to adopt a baby that is due in two weeks.
House and the team treat an agoraphobic who adamantly refuses to leave his home and get treatment at the hospital; Chase and Cameron try to work through some kinks in their relationship; House deals with an itch he can't seem to scratch.
An emancipated minor working as a factory manager falls ill on the job; Foreman takes on a pediatric case that has him questioning whether he can function without House's oversight.