
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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A six-year-old girl suffers ailments expected in patients much older; tensions between Chase and Cameron lead House to intentionally assign them to the same tasks, including investigating the young girl's home.
When a young scam artist passes out while working a card-playing scheme, Foreman suspects her condition stems from drug abuse; Cuddy and Wilson go on a date to an art exhibit.
Wilson prepares a 14-year-old leukemia patient for a last-resort bone-marrow transplant from his younger brother; a mistake that killed a patient a week earlier haunts Foreman.
A 19-year-old college student goes to the hospital after coughing up blood during karate class; House takes a special interest in an attractive nutritionist, who accompanied her boyfriend to the clinic.