
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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House searches for connections between the unique symptoms exhibited by a gay AIDS patient and his father.
A young mother with stomach pain dies, and Stacy (Sela Ward) must determine whether Chase made a mistake that caused her death.
Off-track betting gambler Anica (Cynthia Nixon) collapses in front of House while they are both following horse races at the site.
With House and Stacy out of town, the team is left on its own to help a journalist, whose sudden collapse is followed by an inability to speak clearly.