
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

A 35-year-old musical savant is admitted to the hospital with a rare movement disorder; Cameron discovers that House has been in contact with a Massachusetts hospital.

House's newest patient, an ex-Marine who had saved House's life in a dream the night before, intrigues him.

A celebrity photographer suffers a stroke in her early forties while pregnant; House and his team face the dilemma of either saving the mother or her unborn child.

When a man next to House on a flight from Singapore to the United States becomes violently ill, Cuddy suspects he has a contagious virus.