
At fictional Princeton Plainsboro Teaching Hospital in New Jersey, prickly genius Dr. Gregory House tackles health mysteries as would a medical Sherlock Holmes, all the while playing mind games with colleagues that include his best friend, oncologist James Wilson. House, an acerbic infectious disease specialist, solves medical puzzles with the help of a team of young diagnosticians. Flawless instincts and unconventional thinking help earn House great respect, despite his brutal honesty and antisocial tendencies.

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House and the team take on the case of a struggling artist with an undiagnosed illness that's distorting his perception and threatening his career; House continues to have a private investigator dig up dirt on everyone on his team.
After receiving word that his father has passed away, House is coerced into attending the funeral; the team tries to diagnose the illness of a woman who was in China searching for her birth mother.
Thirteen's date gets ill after a night of partying and House takes on her case; Foreman confronts Thirteen about her self-destructive lifestyle; private investigator Lucas is hot on Wilson's trail.
The team takes on the case of a sleepwalking patient experiencing unexplained blackouts; House discovers that Cuddy is planning to adopt a baby that is due in two weeks.