
Mystery writer and amateur detective Jessica Fletcher - a down-to-earth, middle-aged widow - ferrets out the criminals in idyllic Cabot Cove, Maine, which apparently is the murder capital of the United States for the show's 12-season run. Though while traveling, she uncovers a fair number of killers as well.
After losing two elderly patients, a young nurse (Megan Porter Follows) is found holding a syringe containing poison and charged with murder.
Jessica travels to Rome to help rewrite the script for the filming of one of her books, but the filming takes a tragic turn when a stuntman dies.
Jessica helps an inexperienced sheriff investigate a murder in a small desert town where the government may have conducted dangerous chemical experiments.
A research trip to New Orleans plunges Jessica into the world of the occult, when a businessman dies, and a voodoo doll is evidence.