
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

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Dr. Sloan and private investigator Joe Mannix reopen a 25-year-old murder case in which the mob is suspected of killing an investigative reporter.
Mark's (Dick Van Dyke) old flame (guest star Michelle Phillips) begs him to help clear her husband (guest star Ray Wise) on charges of murdering one of her many lovers. Joanna Cassidy also guest stars.
Mark tries to clear the name of a drug addict who is suspected of killing another addict with an overdose at a rehabilitation center.
Dr. Sloan becomes involved in a bloody gang war when a mobster who looks exactly like him moves nearby; Amanda is concerned that a child may be a victim of abuse.