
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

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Dr. Sloan tries to clear his colleague's (Joanna Cassidy) name after she is arrested for selling narcotics.
Dr. Sloan investigates the murder of a high-school teacher when a lawyer from the district attorney's office insists the death was a case of gang violence.
Soon after Mark's estranged daughter returns home, the Sloans receive word her husband has been murdered.
Dr. Sloan must disprove the charges against a nurse when her former employer, a Malibu madam, is found murdered just prior to the release of her tell-all book.