
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.
Mark gets wrapped up in the world of high fashion and designer drugs while tracking down the person responsible for planting a bomb that killed his friend on his wedding day.
A paparazzo stays frames ahead of Dr. Sloan and Steve in a kidnapping investigation they believe is related to a murder; Amanda goes into labor.
While treating a famous rock star who collapsed before a concert, Mark learns she is being threatened by a deranged stalker.
A priest suspected of murder hears the true killer's confession and can't break his vow of confidentiality, so Mark goes undercover to clear his name and put the real killer behind bars.