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After the unsolved murder of his wife, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.
S5, EP16 "Mr. Monk Goes to the Hospital"
Monk finds himself in danger when he investigates the death of a doctor.
S2, EP11 "Mr. Monk and the Three Pies"
Monk's estranged older brother Ambrose calls him about a life-or-death matter; he is convinced his neighbour has been killed by her husband.
S3, EP9 "Mr. Monk Takes His Medicine"
Monk takes a new medicine that alleviates symptoms of obsessive-compulsive disorder but impairs his ability to solve crimes.
S3, EP16 "Mr. Monk and the Kid"
Monk unravels a mystery when a toddler finds a severed finger in a park.
S5, EP15 "Mr. Monk and the Really, Really Dead Guy"
Monk uses his detective skills to find the mysterious "Six Way Killer."
S5, EP14 "Mr. Monk Visits a Farm"
Lt. Disher inherits his uncle's farm, but suspects that he may not have died of natural causes.
S5, EP12 "Mr. Monk Is at Your Service"
Natalie suspects foul play in the deaths of her parents' neighbors.
S5, EP11 "Mr. Monk Makes a Friend"
Monk's new friend becomes very attached to him, which makes his other friends suspicious.