
Tom Selleck stars as Frank Reagan, the New York Police Commissioner, and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.

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Erin's nephew, police officer Joe Hill, becomes aware of witness tampering in a trial; Baez forces Danny to help her find the killer of her favorite TV personality; Eddie questions her decision to become a police sergeant.
Frank contends with public outcry to defund the NYPD School Safety Division, after a physical altercation between a school officer and a student goes viral; Danny and Baez help a father track down his missing ex-wife and daughter.
Frank, Baker, Garrett and Gormley experience guilt when an officer they briefly worked with is shot after Frank reassigned her for not meshing with their team; Anthony is offered a promotion that strains his relationship with Erin.
Frank is blindsided when Mayor Chase bypasses him with a request for Jamie to head his security detail; Danny and Baez investigate the murder of a wealthy college student; Anthony fears money woes are leading his sibling down the wrong path.