
Tom Selleck stars as Frank Reagan, the New York Police Commissioner, and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.

Danny and Baez investigate the murder of a single mother whose ex-husband has a history of violence; Mayor Dutton eliminates solitary confinement in prisons; Jamie's efforts to save a young woman who overdosed on drugs has unexpected consequences.

A famous basketball player is found dead of an apparent drug overdose; Danny looks into possible ties to a local drug gang; Erin revisits the case of a man she may have wrongfully convicted years ago; Frank is approached by Archbishop Kearns.

The community and the mayor scrutinize Frank's department when an officer is accused of using excessive force; a Wall Street executive who was deeply in debt is murdered.

Frank is put in danger when his dinner companion, mob lawyer Angelo Gallo, is shot; Danny is a juror in a murder trial.