
Dr. Jason Bull is the charming and cocky founder of successful trial consulting firm Trial Analysis Corporation, where he and his team of experts employ psychology, human intuition and high-tech data to understand jurors, lawyers, witnesses and defendants, and construct effective narratives to help their clients win. Bull's team include his brother-in-law Benny, neurolinguistics expert Marissa, former detective Danny, hacker Cable, and Chunk, who helps perfect clients' appearances for trial. "Bull" is inspired by the early career of Dr. Phil McGraw, who also serves as executive producer.

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Bull's legal troubles go from professional to personal when new evidence in his bribery trial implicates his wife; the TAC team's efforts to assist Bull in court are thwarted by his attorney, who fears they will cross a legal line to help their boss.
Bull needs a Christmas miracle when he takes on a sports agency's young assistant charged with providing a star client lethal drugs.
Bull helps a grieving mother sue the developers of a computer program that misidentified her son as a criminal, leading him to be fatally shot by the police; Bull and Marissa clash when she considers a job offer from a rival company.
Bull and Chunk aim to prove that their client, a woman on trial for murder, committed the crime due to a lack of behavioral control caused by a brain tumor; Taylor is suspected by the FBI of committing cybercrimes.